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First, while the effects of fatty acids in vitro and hyperlipidaemia in vivo were consistently observed at the level of Glp1r expression and signalling, the decrease in Gipr was not seen in vitro, and normalisation of circulating lipid levels did not improve the efficacy of D-GIP in db/db mice

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Patients should be informed about potential side effects of antiemetics, including QT prolongation with ondansetron

This stems from GLP 1s effects on gastric emptying and central nausea circuits